Are you motivated to explore the underlying mechanism of life? Our group can be the platform that jumpstart your dream! If you expect to graduate and obtain your bachelor or master degree in physics, chemistry and biology, you are welcome to apply for the graduate studentship in our group. If you obtain your advanced degree in the last five years in biochemistry, biophysics, structural biology, computational biology or a related field, then you are welcome to apply technician, postdoctoral fellow, research assistant and associate positions in our group. If interested, please send your resume and names of two references to tanglab (at) wipm.ac.cn.
We are a young research team. We strive to elucidate the ensemble conformation and the dynamics of macromolecules in solution.
Biological macromolecules are polymers of amino acids, nucleotides, etc. The positions of each atom in a macromoleculeafford its three-dimensional structure. Macromolecules in turn can interact with each other via Van Der Waals and other non-covalent forces to form complexes. The relatively defined structures of macromolecules and their complexes allow their particular functions in cell.
The three-dimensional structure of a macromolecule is constantly fluctuating in solution. Such dynamics include both localized wobbling as well as more global rearrangement, and span a temporal spectrum from pico- nano second to second and minutes. The structural change allows macromolecules to perform their particular biological functions, such as binding, allostery and catalysis. The dynamics are manifestations of life at an atomic level.